Dermal Fillers: From Wrinkle Filler to Facial Sculptor CRM® - Covalent Reticulated Copolymer

CRM® Information and Background

CRM Logos

Product Summary
The German company behind Matridur and Matridex have now launched a new range of non-animal hyaluronic acid based fillers under the brand name CRM®, which relates to their Covalent Reticulated Copolymer Matrix technology.
This has now been available in the UK since March 2008. As a result, you may only come across a few practitioners using this product currently.
CRM® technology uses a cross-linking agent called Butanedioldiglycidylether (BDDE), one of the least toxic of the cross-linking agents, which it is claimed increases the resistance of the gel to degradation. The manufacturers also note that CRM® Technology produces a gel of a greater purity which virtually eliminates immune reactions, making it safer for patients and it is retained longer in the tissue for a longer-lasting result.
Generic name
Non-Animal Hyaluronic Acid (NaHA) gel.
Plus positively charged dextranomeres within two products (see product range details below for more information).
How is it made?
Hyaluronic acid - by bacterial fermentation from streptococci bacteria.

Is a skin test required before treatment?

Is it temporary or permanent?
Hyaluronic acid is completely broken down within the skin over a period of months, eventually leaving no trace of the filler.
Dextranomeres or dextran molecules break down into sugars within 2 years.
Licenced status
Medical device.

European CE mark approved.

Should be used by
Trained members of the medical profession only.

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